Few studies have specifically examined interactions between drugs and dietary supplements in the general population, and existing reports have found only mild interactions. Lack of data, however, does not imply lack of danger. Dietary supplements may alter the activity of conventional drugs. Such interactions may occur in individuals who are particularly sensitive or immune compromised or for drugs that have a narrow therapeutic window. In addition, response to drug and dietary supplement consumption may change with age and health status. Interactions between drugs and dietary supplements are especially likely in geriatric patients because they use more drugs and often combine prescription and over-the-counter drugs with herbal remedies. People with a chronic illness, specifically those with hepatic or renal impairment, are at higher risk of harmful interactions between drugs and dietary supplements.

