Although the FDA does not participate in or oversee the testing of dietary supplements for safety, the FDA is responsible for removing unsafe dietary supplements from the market. Adverse or suspected adverse effects of dietary supplements should be reported to the FDA. Once the FDA receives such information, it generates alerts and warnings for consumers and letters notifying the manufacturer that their dietary supplement may be associated with harmful adverse events. The results of these actions may range from a consumer warning, labeling change, or product recall to a full-fledged product withdrawal. Dietary supplement manufacturers may voluntarily recall a product, as in the case of a labeling error, product mix-up, contamination, or questionable stability of the product or its components. The FDA may also request or order a product recall based on the above criteria.

